The association between low serum Vitamin B12 levels and hyperpigmentation on patients who use Isotretinonin

Objective: Oral isotretinoin is the most effective agent in treatment of acne vulgaris. The risk pigmentation due to systemic may be associated with decrease serum levels Vit B12. study aims contribute literature by defining association between increase caused oral [O-ISO] use and low vitamin B12 level [vit-B12]. Methods: In our we evaluated 144 patients, who have facial acnes at medium degree according FDA Acne Score take O-ISO dose 0.5 mg/ kg/ day for six months. relationship patients admission 6th month existence month, skin type layer which occurs, was evaluated.Association vit-B12 on months post drug presence months, occurs were evaluated. Results: group pigmentation, mean after statistically lower than [p <0.001]. no difference Vit-B12 not significant = 0,255]. Conclusion: As a result, it determined that decreased hyperpigmentation significant. -B12 monitoring supplementation, if necessary, can help us prevent occur during treatment.